From fa7ea76880090106fae1e4b7b13ff209727098f4 Mon Sep 17 00:00:00 2001 From: jameybrinson82 Date: Tue, 14 Oct 2025 19:47:36 +0800 Subject: [PATCH] Add Effects Of Testosterone, Testosterone Propionate, 17 Beta-trenbolone And Progesterone On Cell Transformation And Mutagenesis In Syrian Hamster Embryo Cells --- ...nd Mutagenesis In Syrian Hamster Embryo Cells.-.md | 11 +++++++++++ 1 file changed, 11 insertions(+) create mode 100644 Effects Of Testosterone%2C Testosterone Propionate%2C 17 Beta-trenbolone And Progesterone On Cell Transformation And Mutagenesis In Syrian Hamster Embryo Cells.-.md diff --git a/Effects Of Testosterone%2C Testosterone Propionate%2C 17 Beta-trenbolone And Progesterone On Cell Transformation And Mutagenesis In Syrian Hamster Embryo Cells.-.md b/Effects Of Testosterone%2C Testosterone Propionate%2C 17 Beta-trenbolone And Progesterone On Cell Transformation And Mutagenesis In Syrian Hamster Embryo Cells.-.md new file mode 100644 index 0000000..94fc9c1 --- /dev/null +++ b/Effects Of Testosterone%2C Testosterone Propionate%2C 17 Beta-trenbolone And Progesterone On Cell Transformation And Mutagenesis In Syrian Hamster Embryo Cells.-.md @@ -0,0 +1,11 @@ +Effects Of Testosterone, Testosterone Propionate, 17 Beta-trenbolone And Progesterone On Cell Transformation And Mutagenesis In Syrian Hamster Embryo Cells +
Title:
+Neurochemical Mechanisms Underlying the Rapid Antidepressant Action of Ketamine: [https://go.tanurtravel.com/maryjomontague](https://go.tanurtravel.com/maryjomontague) A Comprehensive Review +
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+Abstract +
Ketamine, an N‑methyl‑D‑aspartate (NMDA) receptor antagonist, has emerged as a pioneering rapid‑acting antidepressant. Its therapeutic efficacy manifests within hours, contrasting starkly with the protracted onset of conventional monoaminergic agents. This review consolidates preclinical and clinical evidence elucidating ketamine’s neurochemical cascade: blockade of extrasynaptic NMDA receptors on GABAergic interneurons, resultant glutamate surge, AMPA receptor activation, BDNF release, downstream mTOR signaling, and synaptogenesis in the medial prefrontal cortex and hippocampus. We also discuss adjunctive pharmacotherapies—ketamine’s enantiomer esketamine, glycine modulators, and AMPA potentiators—that may amplify antidepressant response or mitigate side effects. Emerging data on biomarkers (e.g., CSF BDNF levels) and personalized approaches underscore the translational potential of this mechanistic framework. +
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Keywords: ketamine, esketamine, enantiomers, glutamate, AMPA receptors, mTOR pathway, synaptogenesis, depression, pharmacodynamics, therapeutic strategies. +
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